ECL cell - PMC

Weiwei Sheng, Ermanno Malagola, Henrik Nienhüser, Zhengyu Zhang, Woosook Kim, Leah Zamechek, Antonia Sepulveda, Masahiro Hata, Yoku Hayakawa, Chun-Mei Zhao, Duan Chen, Timothy C. Wang

Cell Mol Gastroenterol Hepatol. 2020; 10(2): 434–449.e1. Published online 2020 Apr 21. doi: 10.1016/j.jcmgh.2020.04.008

PMCID:: PMC7371950

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Effects of Helicobacter pylori infection and long-term proton pump inhibitor use on enterochromaffin-like cells

Mehmet Bektaş, Nurşen Saraç, Hülya Çetinkaya, Murat Törüner, Esra Erdemli, Onur Keskin, İrfan Soykan, Esen Ismet Oktay, Esin Korkut, Yusuf Üstün, Kadir Bahar

Ann Gastroenterol. 2012; 25(2): 123–127.

PMCID:: PMC3959398

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Expression of Adenosine A_2B Receptor and Adenosine Deaminase in Rabbit Gastric Mucosa ECL Cells

Rosa María Arin, Ana Isabel Vallejo, Yuri Rueda, Olatz Fresnedo, Begoña Ochoa

Molecules. 2017 Apr; 22(4): 625. Published online 2017 Apr 12. doi: 10.3390/molecules22040625

PMCID:: PMC6154537

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CHRONIC USE OF PROTON PUMP INHIBITORS AND THE QUANTITY OF G, D, AND ECL CELLS IN THE STOMACH

Silvia Maria Perrone CAMILO, Élia Cláudia de Souza ALMEIDA, Jacqueline Batista SOUSA, Luana Perrone CAMILO, Renata Margarida ETCHEBEHERE

Arq Bras Cir Dig. 2020; 33(2): e1506. Published online 2020 Aug 24. doi: 10.1590/0102-672020190001e1506

PMCID:: PMC7448853

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Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome

Lingaku Lee, Irene Ramos-Alvarez, Tetsuhide Ito, Robert T. Jensen

Int J Mol Sci. 2019 Oct; 20(20): 5128. Published online 2019 Oct 16. doi: 10.3390/ijms20205128

PMCID:: PMC6829234

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Tachyphylaxis of the ECL-cell response to PACAP: receptor desensitization and/or depletion of secretory products

M Bernsand, R Håkanson, P Norlén

Br J Pharmacol. 2007 Sep; 152(2): 240–248. Published online 2007 Jul 30. doi: 10.1038/sj.bjp.0707385

PMCID:: PMC1978265

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Physiological and clinical significance of enterochromaffin-like cell activation in the regulation of gastric acid secretion

Guanglin Cui, Helge L Waldum

World J Gastroenterol. 2007 Jan 28; 13(4): 493–496. Published online 2007 Jan 28. doi: 10.3748/wjg.v13.i4.493

PMCID:: PMC4065968

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Tumor Classification Should Be Based on Biology and Not Consensus: Re-Defining Tumors Based on Biology May Accelerate Progress, An Experience of Gastric Cancer

Helge Waldum

Cancers (Basel) 2021 Jul; 13(13): 3159. Published online 2021 Jun 24. doi: 10.3390/cancers13133159

PMCID:: PMC8269176

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The morphologic spectrum of gastric type 1 enterochromaffin-like cell neuroendocrine tumors

Julio C. Poveda, Satyapal Chahar, Monica T. Garcia-Buitrago, Elizabeth A. Montgomery, Oliver G. McDonald

Mod Pathol. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Mod Pathol. 2023 Jan 10; 36(4): 100098. Published online 2023 Jan 10. doi: 10.1016/j.modpat.2023.100098

PMCID:: PMC10121960

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The central role of gastrin in gastric cancer

Helge Waldum, Patricia Mjønes

Front Oncol. 2023; 13: 1176673. Published online 2023 Oct 24. doi: 10.3389/fonc.2023.1176673

PMCID:: PMC10628637

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Chloroacetanilide herbicide-induced rat enterochromaffin cell tumors: a case study within the context of the IPCS framework, for analyzing the relevance of a cancer mode of action for humans

Midori Yoshida

J Toxicol Pathol. 2021 Jul; 34(3): 213–222. Published online 2021 Apr 2. doi: 10.1293/tox.2021-0009

PMCID:: PMC8280306

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Properties of isolated gastric enterochromaffin-like cells.

N. Zeng, G. Sachs

Yale J Biol Med. 1998 May-Aug; 71(3-4): 233–246.

PMCID:: PMC2578990

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Submucosal microinfusion of endothelin and adrenaline mobilizes ECL-cell histamine in rat stomach, and causes mucosal damage: a microdialysis study

M Bernsand, P Ericsson, M Björkqvist, C -M Zhao, R Håkanson, P Norlén

Br J Pharmacol. 2003 Oct; 140(4): 707–717. Published online 2003 Sep 22. doi: 10.1038/sj.bjp.0705473

PMCID:: PMC1574064

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A Prospective Study of Gastric Carcinoids and Enterochromaffin-Like Cell Changes in Multiple Endocrine Neoplasia Type 1 and Zollinger-Ellison Syndrome: Identification of Risk Factors

Marc J. Berna, Bruno Annibale, Massimo Marignani, Tu Vinh Luong, Vito Corleto, Andrea Pace, Tetsuhide Ito, David Liewehr, David J. Venzon, Gianfranco Delle Fave, Cesare Bordi, Robert T. Jensen

J Clin Endocrinol Metab. 2008 May; 93(5): 1582–1591. Published online 2008 Feb 12. doi: 10.1210/jc.2007-2279

PMCID:: PMC2386679

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Long-term proton pump inhibitors use and its association with premalignant gastric lesions: a systematic review and meta-analysis

Zeyi Zheng, Ziyu Lu, Yani Song

Front Pharmacol. 2023; 14: 1244400. Published online 2023 Aug 25. doi: 10.3389/fphar.2023.1244400

PMCID:: PMC10492503

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A hypothesis of couplet molecules and couplet cells in gastric function and an association with Helicobacter pylori

Cyril John Craven

BMC Gastroenterol. 2016; 16: 16. Published online 2016 Feb 16. doi: 10.1186/s12876-016-0429-0

PMCID:: PMC4754955

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Role of PACAP₁ Receptor in Regulation of ECL Cells and Gastric Acid Secretion by Pituitary Adenylate Cyclase Activating Peptide

JOSEPH R. PISEGNA, GORDON V. OHNING, CHRISTOPHE ATHMANN, NINGXIN ZENG, JOHN H. WALSH, GEORGE SACHS

Ann N Y Acad Sci. Author manuscript; available in PMC 2019 Sep 10.

Published in final edited form as: Ann N Y Acad Sci. 2000; 921: 233–241. doi: 10.1111/j.1749-6632.2000.tb06971.x

PMCID:: PMC6736551

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Relationships of endocrine cells to each other and to other cell types in the human gastric fundus and corpus

Josiane Fakhry, Martin J Stebbing, Billie Hunne, Yulia Bayguinov, Sean M Ward, Kent C. Sasse, Brid Callaghan, Rachel M McQuade, John B Furness

Cell Tissue Res. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Cell Tissue Res. 2019 Apr; 376(1): 37–49. Published online 2018 Nov 22. doi: 10.1007/s00441-018-2957-0

PMCID:: PMC6451671

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Figure 3

Correlation of the magnitude of the ECL-cell index, the most advanced ECL-cell change, and the α-hCG-IR in 533 biopsies from 57 patients with MEN1/ZES. Each point represents data from one patient. The mean and sem are indicated by horizontal and vertical bars, respectively. The n refers to the number of patients in each category. The upper left panel shows the correlation between the most advanced cell change per patient and the ECL-cell index computed for each patient. The upper right panel shows the correlation between the most intense α-hCG staining and the ECL-cell index in each patient. The lower left panel shows the correlation between the most advanced cell change per patient and the most intense α-hCG staining. ECL-cell index was available for 13 patients with ECL-cell tumors, whereas α-hCG staining intensity was available for only 12 patients with ECL-cell tumors.

A Prospective Study of Gastric Carcinoids and Enterochromaffin-Like Cell Changes in Multiple Endocrine Neoplasia Type 1 and Zollinger-Ellison Syndrome: Identification of Risk Factors

J Clin Endocrinol Metab. 2008 May;93(5):1582-1591.
Figure 7ECL-cell changes in patients with or without postcurative acid hypersecretion

The top two panels are the ECL-cell pattern in two patients with postoperative normosecretion with one patient (top left) showing a normal ECL-cell pattern and the other (top right) showing mild diffuse hyperplasia. The bottom two panels show severe diffuse hyperplasia in a patient (bottom left) with moderate hypersecretion and moderate linear hyperplasia in a patient with extreme hyperplasia. Shown are CgA immunoperoxidase stains with hematoxylin counterstaining. These results are representative of those for all patients with patients having hypersecretion showing significantly (P = 0.005) more advanced ECL-cell changes than normosecretors.

Mechanism of Acid Hypersecretion Post-Curative Gastrinoma Resection

Dig Dis Sci. ;56(1):139-154.
Figure 1

Enterochromaffin-like (ECL) cell and cytoplasmic organelles. (a) normal ECL cell, (b) granules, (c) vacuoles, (d) lipofuscin

Effects of Helicobacter pylori infection and long-term proton pump inhibitor use on enterochromaffin-like cells

Ann Gastroenterol. 2012;25(2):123-127.
Figure 3

Fundus enterochromaffin-like (ECL) cell hyperplasia and dysplasia. (A,B) Oxyntic mucosa showing severe atrophy with extensive pseudopyloric and intestinal metaplasia. Note the presence of aggregates of closely packed micronodules in the deep lamina propria, at higher magnification in B (hematoxylin and eosin). (C) Chromogranin-A-positive ECL cell adenomatoid hyperplasia, consisting of aggregates of more than four neuroendocrine cell micronodules in the lamina propria (chromogranin-A immunohistochemistry). (D) ECL cell fused micronodules (with no intervening basal membrane), consistent with neuroendocrine cell preneoplastic/dysplastic lesions (chromogranin A immunohistochemistry).

Case Report: Two Is Not (Always) Better Than One: Pyloric Gland Adenoma of the Gastric Cardia and Concurrent Neuroendocrine Cell Dysplasia Arising From Autoimmune Gastritis

Front Med (Lausanne). 2022;9:890794.